教育: Dual BS, University of Florida, 1996; PhD, University of Washington, 2001. At SPU since 2003.
本·麦克法兰 came to 西雅图 Pacific after studying Biomolecular Structure 和 Design at the University of Washington 和 completing a post-doctoral fellowship in Structural Immunology at the Fred Hutchinson Cancer 研究 Center. His research has studied the binding of MHC molecules to peptides 和 MIC-A proteins to NKG2D immunoreceptors.
Dr. 麦克法兰’s teaching 和 research focus on the structural aspects of protein biochemistry 和 design. His team of undergraduate students has accomplished protein production 和 design in the teaching 和 research labs at SPU, 和 have made new molecules with enhanced binding functions. This research has been funded by the NIH 和 NSF.
Dr. 麦克法兰 writes about science for general audiences, including the book A World from Dust (Oxford University Press) 和 related book chapters. He is also a member of the BioLogos Voices speakers bureau.
书撰写
A World From Dust: How the Periodic Table Shaped Life. Published March 2016 by Oxford University Press.
Selected 出版物
- Gavlovsky P.J., P. 潜水鸟,N. 杰拉德,年代. Nedellec, A.W. 蹄兔, B.J. 麦克法兰, 和B. Charreau, 2016, “Alternative Splice Transcripts for MHC Class I-Like MICA Encode Novel NKG2D Lig和s with Agonist or Antagonist Function.” Journal of Immunology. 197 (3), 736-746.
- Henager,年代.H., M.A. 黑尔,N.J. 莫里斯·E.C. Dunnington C.J. Swanson, M.J. 彼得森J.J. 禁令,维.J. Culpepper L.D. 戴维斯,我.K. 桑德斯, 和 B.J. 麦克法兰, 2012, “For the Record: Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface.” Protein Science, 21 (9), 1396-1402.
- “The Trees of Life."第十六章 信仰 Seeking Underst和ing: Essays in Memory of Paul Br和 和 Ralph D. 冬天, edited by David Marshall. William Carey 图书馆 (Pasadena, CA), 2012.
- Culpepper D.J., M.K. 马多克斯,.B. 考德威尔 和 B.J. 麦克法兰, 2011, “Systematic mutation 和 thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.” Molecular Immunology, 48 (4): 516-523.
- 阿帕德,C.S.E., L. 威利斯,P. 曼, T. Kortemme D. 贝克,R.K. 强大, B.J. 麦克法兰, 2007, “Mutations designed to destabilize the receptor-bound conformation increase MICA-NKG2D association rate 和 affinity.” J. 医学杂志. 化学. 282 (42): 30658-30666.
视图 Dr. 麦克法兰的简历 (PDF) for more information.
个人联系
Dr. 麦克法兰’s website